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The Analysis of Clinical Biological and Pathological Features in Papillary Thyroid Carcinoma
Ying Li,
Yi Su,
Rong Qin Dai,
Feng Zhou,
Chao Shen,
Zhong Yu Su,
Gui Ran Yang
Issue:
Volume 9, Issue 6, December 2021
Pages:
292-297
Received:
29 October 2021
Accepted:
15 November 2021
Published:
17 November 2021
Abstract: Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: The understanding is further strengthened, and the level of diagnosis and treatment is improved, through the analysis of the biological and clinicopathological characteristics of papillary thyroid carcinoma. Method: Hospitalized cases with papillary thyroid carcinoma were collectedand biological and pathological characteristics were analyzed. Result: Among 110 cases of papillary thyroid carcinoma, 11 cases were male (10%), 99 cases were female (90%). There was no significant difference in invasiveness, lymph node metastasis, proportion of papillary microcarcinoma, number of lesions and involvement of glandular lobe, which were divided into groups according to different ages and different genders, (P>0.05). The average age of 46 cases with invasion was younger than that without invasion (P<0.001). There was less invasion and lymph node metastasis in papillary microcarcinoma (P<0.001). 16 cases of Hashimoto's thyroiditis were female, the average age of onset was higher, the difference was statistically significant (P<0.001) and TSH level was also higher than the patients without Hashimoto's thyroiditis (P<0.05). Conclusion: There was no significant difference in the clinicopathological characteristics of papillary thyroid carcinoma in different age groups and gender groups, but in the invasive study, the average age of patients with invasion was lower. Patients with papillary microcarcinoma are less likely to have invasion and lymph node metastasis. TSH levels are generally high in patients with Hashimoto's thyroiditis.
Abstract: Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: The understanding is further strengthened, and the level of diagnosis and treatment is improved, ...
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Beware of Dog: Practical Consideration in Asthmatic Patients with Poor Perception of Respiratory Symptoms
Giuseppe Madonia,
Ursula Madonia
Issue:
Volume 9, Issue 6, December 2021
Pages:
298-301
Received:
7 May 2021
Accepted:
24 May 2021
Published:
23 November 2021
Abstract: Symptoms are often difficult to quantify, represent and depict for the patients and sometime also for the attending physicians. Anyway their role is crucial in influencing the relationship patient/physician in many ways. Respiratory symptoms (cough, thoracic pain, dispnoea) are not free of this challenging drawback. In asthmatic patients the subjective awareness of their disease condition, expecially their insight in the quality of breathing pattern, is critical to assess severity and control of their disease: under-perception of respiratory symptoms make this task problematic for patients and physicians. To estimate the magnitude of problem two set of reports have been examined: one on “real life” patients with chronic stable asthma and secondly studies evaluating the level of perception in selected asthmatic patients in a laboratory setting using bronchial provocation tests tool. Cumulatively a rough percentage of 20% asthmatic patients showed a reduced ability to be aware of their low level of pulmonary function. This impaired ability to perceive and report symptoms could also be a harbinger of undesirable and sometimes dangerous consequences. These data show that poor perception in asthma is a challenging problem affecting a large proportion of patients, with the potential of severe outcomes that need to be accurately addressed.
Abstract: Symptoms are often difficult to quantify, represent and depict for the patients and sometime also for the attending physicians. Anyway their role is crucial in influencing the relationship patient/physician in many ways. Respiratory symptoms (cough, thoracic pain, dispnoea) are not free of this challenging drawback. In asthmatic patients the subjec...
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On Chip Detection of Zika Virus Based on Loop Mediated Isothermal Amplification
Hong Yin,
Xing Chen,
Yong Jin,
Bo Liu,
Rongmeng Jiang
Issue:
Volume 9, Issue 6, December 2021
Pages:
302-306
Received:
22 October 2021
Accepted:
19 November 2021
Published:
24 November 2021
Abstract: There was a world-wide Zika virus (ZIKV) epidemic occurred in 2015, with the major concern of about 20-fold increase in fetuse microcephaly rate in Brazil. To improve the ZIKV point-of-care (POC) molecular diagnostic, we established a rapid and sensitive real-time fluorescence quantitative loop mediated isothermal amplification (LAMP) method and further applied it on a self-fabricated microfluidic chip. After optimization of LAMP reaction conditions, the assay achieved the detection limit of single copy of the standard plasmid in a reaction. Linear regression analysis revealed that the correlation coefficients (R2) were 0.9931. No cross reaction was observed in the controls of yellow fever clinical specimen and several known human influenza viruses, including seasonal A/H1N1, A/H7N9, A/H9N2 and B. To evaluate the performance characteristics of the ZIKV-LAMP assay, we detected 39 clinical specimens by both LAMP assay and real-time RT-PCR, which obtained with completely consistent results. The sensitivity, specificity and performance characteristics of the ZIKV-LAMP assay conformed its utility in ZIKV determination. Moreover, we had also developed a real-time fluorescence detection biomedical system with microfluidic chips. The microfluidic chips were designed with four microcells and the volume of the LAMP reaction was greatly reduced from about 25μL to 10μL. Our newly established real-time fluorescence LAMP detection system with microfluidic chips has the potential for ZIKV POC diagnostics with the advantages of low cost, short analytical time, disposability, low reagent and sample consumption and so on.
Abstract: There was a world-wide Zika virus (ZIKV) epidemic occurred in 2015, with the major concern of about 20-fold increase in fetuse microcephaly rate in Brazil. To improve the ZIKV point-of-care (POC) molecular diagnostic, we established a rapid and sensitive real-time fluorescence quantitative loop mediated isothermal amplification (LAMP) method and fu...
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Finite Element Modeling for Fluorescence Molecular Tomography
Zhaolu Zuo,
Shaobin Dou,
Deyi Kong,
Kai Wu
Issue:
Volume 9, Issue 6, December 2021
Pages:
307-314
Received:
25 October 2021
Accepted:
23 November 2021
Published:
24 November 2021
Abstract: Non-contact Fluorescence Molecular Tomography (FMT) and Bioluminescence Tomography (BLT) has attracted more and more attention due to its unique advantages. For real experiments, how to obtain the 3D model of an object and the surface fluorescence distribution is one of the main obstacles. In this paper, an effective method to obtain the Finite Element Model is presented. We discuss the geometric and mathematical principles in detail. We prove that the FEM model generated by the method has enough quality for reconstruction. We demonstrate the quality of the model through a series of examples. This method can realize the whole process only by using a single-mode optical system. Firstly, a series of white light and fluorescence images are collected along the object in white light flat field illumination mode and excitation fluorescence mode respectively. The white light illumination images are used to reconstruct the 3D model contour of the object. After voxelization with appropriate resolution, we use the Delaunay algorithm to divide the model into tetrahedral finite elements. For the fluorescence image, we proposed a method based on vertex normal vector to realize the photon flux density mapping from 2D fluorescence image to 3D Finite Element Method (FEM) mesh nodes of the surface. The experimental results prove the accuracy of the model and the mapping, and the FEM obtained can meet the needs of FMT/ BLT reconstruction.
Abstract: Non-contact Fluorescence Molecular Tomography (FMT) and Bioluminescence Tomography (BLT) has attracted more and more attention due to its unique advantages. For real experiments, how to obtain the 3D model of an object and the surface fluorescence distribution is one of the main obstacles. In this paper, an effective method to obtain the Finite Ele...
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Epidemiological, Therapeutics Aspects and Socioeconomics Consequences of Urogenital Fistula
Salifou I. Traore,
Ousmane Dembélé,
Soumaila A. Traore,
Aly B. Diallo,
Malla Sylla,
Amadou Maiga,
Moussa Kanté,
Layes Toure,
Bathio Traore,
Moussa Diassana,
Ternan Traore,
Abdou Dolo,
Seydou Ouattara
Issue:
Volume 9, Issue 6, December 2021
Pages:
315-320
Received:
6 October 2021
Accepted:
25 October 2021
Published:
11 December 2021
Abstract: Introduction: The aim of this study was to analyze epidemiological, therapeutics aspects and socioeconomics consequences of this disease. Material and methods: Retrospective study realized in our service from 1er January 2016 to 30 May 2018. All managed UGF were enrolled. Results: 147 cases of UGF were enrolled accounting for 20, 41% of our activities. Mean age: 34, 06±21, 81. The majority of patients came from SKO rural area and 98, 63% of them are housewife doing no rewarded jobs. Obstetrics fistula was predominant with prolonged obstructed labor as the main etiology. Urine leakage was the main reason for seeking consultation. Simple fistulorraphy under loco regional anesthesia has been performed and the result was globally good (78%). HUC Point G classification have been adopted for fistula description. There is an appropriate surgical abscess way for every type of fistula and this study showed a significant difference between different type of fistula in term of surgical operation length, number of surgery and therapeutic prognostic. Conclusion: UGF remains a public health problems. Girl’s socioeconomic life promotion, Education and raising awareness against some bad traditional practice and skilled obstetric facilities attendance could be helpful for prevention. Standard classification seem to be necessary in the way to help in surgeon training and objectively evaluate our result.
Abstract: Introduction: The aim of this study was to analyze epidemiological, therapeutics aspects and socioeconomics consequences of this disease. Material and methods: Retrospective study realized in our service from 1er January 2016 to 30 May 2018. All managed UGF were enrolled. Results: 147 cases of UGF were enrolled accounting for 20, 41% of our activit...
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